Hbotstemcellsrelationship

HBOTstemcellsrelationship.htm

This is presenting the opposite perspective from Dr Bonlie who thinks HBOT can kill off stem cells based on his observation with his MME (see HBOT):

http://www.rxpgnews.com/article_3086.shtml

From a post on CK2:

> Hyperbaric oxygen treatments mobilize stem cells

> Jan 1, 2006, 21:02, Reviewed by: Dr. Priya Saxena

> "We found that hyperbaric oxygen mobilizes

stem/progenitor cells because it increases synthesis of a molecule

called nitric oxide in the bone marrow. This synthesis is thought to

trigger enzymes that mediate stem/progenitor cell release."

> By University of Pennsylvania School of Medicine, According to a

study to be published in the American Journal of Physiology-Heart and

Circulation Physiology, a typical course of hyperbaric oxygen

treatments increases by eight-fold the number of stem cells

circulating in a patient's body. Stem cells, also called progenitor

cells are crucial to injury repair. The study currently appears on-

line and is scheduled for publication in the April 2006 edition of

the American Journal.

> Stem cells exist in the bone marrow of human beings and animals and

are capable of changing their nature to become part of many different

organs and tissues. In response to injury, these cells move from the

bone marrow to the injured sites, where they differentiate into cells

that assist in the healing process. The movement, or mobilization, of

stem cells can be triggered by a variety of stimuli – including

pharmaceutical agents and hyperbaric oxygen treatments. Where as

drugs are associated with a host of side effects, hyperbaric oxygen

treatments carry a significantly lower risk of such effects.

> "This is the safest way clinically to increase stem cell

circulation, far safer than any of the pharmaceutical options," said

Stephen Thom, MD, Ph.D., Professor of Emergency Medicine at the

University of Pennsylvania School of Medicine and lead author of the

study. "This study provides information on the fundamental mechanisms

for hyperbaric oxygen and offers a new theoretical therapeutic option

for mobilizing stem cells."

> "We reproduced the observations from humans in animals in order to

identify the mechanism for the hyperbaric oxygen effect," added

Thom. "We found that hyperbaric oxygen mobilizes stem/progenitor

cells because it increases synthesis of a molecule called nitric

oxide in the bone marrow. This synthesis is thought to trigger

enzymes that mediate stem/progenitor cell release."

> Hopefully, future study of hyperbaric oxygen's role in mobilizing

stem cells will provide a wide array of treatments for combating

injury and disease.

Ø Subscribe to Stem Cell Research Newsletter