Approved by:
American Academy of Neural Therapy and
Institute of Neurobiology (Bellevue, WA, USA)
Institute for Neurobiologie (Stuttgart, Germany)
Academy for Balanced NeuroBiology Ltd
(London, United Kingdom)
This lecture was
presented by Dietrich Klinghardt M.D., Ph.D. at the Jean Piaget Department at
the University of Geneva, Switzerland Oct.2002 to physicians and dentists from
Europe, Israel, several Arab countries and Asia
What are
Neurotoxins?
Neurotoxins are
substances attracted to the mammalian nervous system. They are absorbed by
nerve endings and travel inside the neuron to the cell body. On their way they
distrupt vital functions of the nerve cell, such as axonal transport of
nutrients, mitochondrial respiration and proper DNAtranscription. The body is
constantly trying to eliminate neurotoxins via the available exit routes: the
liver, kidney, skin and exhaled air. Detox mechanisms include acetylation,
sulfation, glucuronidation, oxidation and others. The liver is most important
in these processes. Here most elimination products are expelled with the bile
into the small intestine and should leave the body via the digestive tract.
However, because of the lipophilic/neurotropic nature of the neurotoxins, most
are reabsorbed by the abundant nerve endings of the enteric nervous system
(ENS) in the intestinal wall. The ENS has more neurons than the spinal chord.
From the moment of mucosal uptake the toxins can potentially take 4 different
paths:
1.
neuronal uptake
and via axonal transport to the spinal chord (sympathetic neurons) or brainstem
(parasympathetics) – from here back to the brain.
2.
Venous uptake
and via the portal vein back to the liver
3.
Lymphatic uptake
and via the thoracic duct to the subclavian vein
4.
Uptake by bowel
bacteria and tissues of the intestinal tract
Here is an incomplete
list of common neurotoxins in order of importance:
(i) Heavy metals: such as mercury, lead,
cadmium and aluminium.
(ii) Biotoxins: such
as tetanus toxin, botulinum toxin (botox), ascaridin (from intestinal
parasites), unspecified toxins from streptococci, staphylococci, lyme disease,
clamydia, tuberculosis, fungal toxins and toxins produced by viruses. Biotoxins
are minute molecules (200-1000 kilodaltons) containing nitrogen and sulfur.
They belong to a group of chemical messengers which microorganisms use to
control the host´s immune system, host behaviour and the host´s eating habits.
(iii) Xenobiotics
(man-made environmental toxins): such as dioxin, formaldehyde, insecticides,
wood preservatives, PCBs etc.
(iv) Food
Preservatives, excitotoxins and cosmetics: such as aspartame (diet sweeteners)
food colourings, flouride,
methyl-and propyl-paraben, etc.
I have found that
mercury in it´s different chemical forms has a synergistic amplifying effect
with all other neurotoxins. When mercury is removed, the body starts to more
effectively eliminate all other neurotoxins, even if they are not adressed.
What are the
symptoms?
Any illness can be
caused by, or contributed to, or exagerated by neurotoxins. Fatigue,
depression, insomnia, memory loss and blunting of the senses are common early
symptoms (see list of mercury related symptoms on the following pages).
How is the
diagnosis established?
1.
History of
Exposure: (Did you ever have any amalgam fillings? A tick bite? etc)
2.
Symptoms: (How
is your short term memory? Do you have areas of numbness, strange
sensations,etc)
3.
Laboratory
Testing: (Metals: hair, stool, serum, whole blood, urine analysis, xenobiotics:
fatty tissue biopsy, urine)
4.
Autonomic
Response Testing: (Dr. Dietrich Klinghardt M.D., Ph.D.)
5.
BioEnergetic
Testing (EAV, kinesiology etc.)
6.
Response to
Therapeutic Trial
7.
Functional
Acuity Contrast Test (measure of Retinal Blood Flow)
Why would we want to
treat anyone at all? Is it really needed? Can the body not eliminate these
toxins naturally on its own?
Here is a short list
of independent risk factors which can either cause accumulation of metals
in an otherwise healthy body - or slow down, or inhibit the bodys own
elimination processes.
·
genetics
·
occupational
exposure to toxic material
·
prior illnesses
·
surgical
operations
·
medication or
´recreational´ drug use
·
emotional
trauma, especially in eary childhood
·
social status
·
high
carbohydrate intake combined with protein malnutrition (especially in
vegetarians)
·
use of
homeopathic mercury
·
food allergies
·
the patients
electromagnetic environment (mobile phone use, home close to power lines etc)
·
constipation
·
compromise of
head/neck lymphatic drainage (sinusitis, tonsil ectomy scars, poor dental
occusion)
·
number of dental
amalgam fillings over the patients life-time, number of the patients mothers
amalgam fillings
We will discuss here
only those elimination agents, which are natural, safe and have also been shown to be as
effective (or more effective) than the few available pharmaceuticals. Because
these products cannot be patented and exploited for unethical personal gain,
little attention has been given to them by European or North American medical researchers.
Many of the best scientific studies on this topic are from Asian countries.
The basic program:
High protein,
mineral, fatty acid and fluid intake
Rationale:
·
proteins provide
the important precursors to the endogenous metal detox and shuttle agents, such
as coeruloplasmin, metallothioneine, glutathione and others. The branched-chain
amino acids in cow and goat whey have valuable independent detox effects.
·
Metals attach
themselves only in places that are programmed for attachment of metal ions. Mineral
deficiency provides the opportunity for toxic metals to attach themselves to
vacant binding sites. A healthy mineral base is a prerequisite for all metal
detox attempts (selenium, zinc, manganese, germanium, molybdenum etc.).
Substituting minerals can detoxify the body by itself. Just as important are
electrolytes (sodium, potassium, calcium, magnesium), which help to transport
toxic waste across the extracellular space towards the lymphatic and venous
vessels.
·
Lipids (made
from fatty acids) make up 60-80 % of the central nervous system and need to be
constantly replenished. Deficiency makes the nervous system vulnerabe to the
fat soluble metals, such as metallic mercury constantly escaping as odorless
and invisible vapour evapourating from the amalgam fillings.
·
Without enough
fluid intake the kidneys may become contaminated with metals. The basal
membranes swell up and the kidneys can no longer efficiently filtrate toxins.
Adding a balanced electrolyte solution in small amounts to water helps to restore
intra-and extracellular fluid balance
Cilantro (chinese
parsley)
This kitchen herb is capable of mobilizing mercury, cadmium, lead and aluminum in both bones and the central nervous system. It is probably the only effective agent in mobilizing mercury stored in the inracellular space (attached to mitochondria, tubulin, liposomes etc) and in the nucleus of the cell (reversing DNA damage of mercury). Because cilantro mobilizes more toxins then it can carry out of the body, it may flood the connective tissue (where the nerves reside) with metals, that were previously stored in safer hiding places. This process is called re-toxification. It can easily be avoided by simultaneously giving an intestinal toxin-absorbing agent. Our definite choice is the algal organism chlorella. A recent animal study demonstrated rapid removal of aluminum from the skeleton superior to any known other detox agent.
Dosage and application of cilantro tincture: give 2 drops 2 times /day in the
beginning, taken just before a meal or 30 minutes after taking chlorella (cilantro causes the gallbadder to dump bile - containing the excreted neurotoxins - into the small intestine. The bile-release occurs naturally as we are eating and is much enhanced by cilantro. If no chlorella is taken, most neurotoxins are reabsorbed on the way down the small intestine by the abundant nerve endings of the enteric nervous system). Gradually increase dose to 10 drops 3 times/day for full benefit. During the initial phase of the detox cilantro should be given 1 week on, 2 –3 weeks off.
Other ways of taking
cilantro: rub 5 drops twice/day into ankles for mobilization of metals in all
organs, joints and structures below the diaphragm, and into the wrists for
organs, joints and structures above the diaphragm. The wrists have dense
autonomic innervation (axonal uptake of cilantro) and are crossed by the main
lymphatic channels (lymphatic uptake).
Cilantro tea: use 10
to 20 drops in cup of hot water. Sip slowly. Clears the brain quickly of many
neurotoxins. Good for headaches and other acute syptoms (joint pains, angina,
headache): rub 10 –15 drops into painful area. Often achieves almost instant
pain relief.
Chlorella:
Both C.pyreneidosa
(better absorption of toxins, but harder to digest) and C.vulgaris (higher CGF
content – see below, easier to digest, less metal absorbing capability) are
available. Chlorella has multiple health inducing effects:
Antiviral (especially effective against the cytomegaly
virus from the herpes family)
·
Toxin binding (mucopolysaccharide membrane)
all known toxic
metals, environmental toxins such as dioxin and others
·
Repairs and
activates the bodys detoxification functions:
·
Dramatically
increases reduced glutathion,
·
Sporopollein is
as effective as cholestyramin in binding neurotoxins and more effective in
binding toxic metals then any other natural substance found.
·
Various peptides
restore coeruloplasmin and metallothioneine,
·
Lipids (12.4 %)
alpha-and gamma-linoleic acid help to balance the increased intake of fish oil
during our detox program and are necessary for a multitude of functions,
including formation of ther peroxisomes.
·
Methyl-coblolamine
is food for the nervous system, restores damaged neurons and has ist own
detoxifying efect.
·
Chlorella growth
factor helps the body detoxify itself in a yet not understood profound way. It
appears that over millions of years chlorella has developed specific
detoxifying proteins and peptides for every existing toxic metal.
·
The porphyrins
in chlorophyl have their own strong metal binding effect. Chlorophyll also
activates the PPAR-receptor on the nucleus of the cell which is responsible for
the transcription of Dna and coding the formation of the peroxisomes (see fish
oil), opening of the cell wall (unknown mechanism) which is necessary for all
detox procedures, normalizes insulin resistance and much more. Medical drugs
that activate the PPAR receptor (such as pioglitazone) have been effective in
the treatment of breast and prostate cancer.
·
Super
nutrient: 50-60% aminoacid
content, ideal nutrient for vegetarians, methylcobolamin - the most easily
absorbed and utilized form of B12, B6, minerals, chlorophyll, beta carotene
etc.
·
Immune system
strengthening
·
Restores
bowel flora
·
Digestive aid
(bulking agent)
·
Alkalinizing
agent (important for patients with malignancies)
Dosage: start with 1
gram (=4 tabl) 3-4 times/day. This is the standard maintainance dosage for
grown ups for the 6-24 months of active detox. During the more active phase of
the detox (every 2-4 weeks for 1 week), whenever cilantro is given, the dose
can be increased to 3 grams 3-4 times per day (1 week on, 2-4 weeks back down
to the maintainance dosage). Take 30 minutes before the main meals and at
bedtime. This way chlorella is exactly in that portion of the small intestine
where the bile squirts into the gut at the beginning of the meal, carrying with
it toxic metals and other toxic waste. These are bound by the chlorella cell wall and carried out via the
digestive tract. When amalgam fillings are removed, the higher dose should be
given for 2 days before and 2-5 days after the procedure (the more fillings are
removed, the longer the higher dose should be given). No cilantro should be
given around the time of dental work. During this time we do not want to
moblize deeply stored metals in addition to the expected new exposure. If you
take Vitamin C during your detox program, take it as far away from Chlorella as
possible (best after meals).
Side effects: most
side effects reflect the toxic effect of the mobilized metals which are
shuttled through the organism. This problem is instantly avoided by
significantly increasing the chlorella dosage, not by reducing it, which would
worsen the problem (small chlorella doses mobilize more metals then are bound
in the gut, large chlorella doses bind more toxins then are mobilized). Some
people have problems digesting the cell membrane of chlorella. The enzyme
cellulase resolves this problem. Cellulase is available in many health food
stores in digestive enzyme products. Taking chlorella together with food also
helps in some cases, even though it is less effective that way. C.vulgaris has
a thinner cell wall and is better toerated by people with digestive problems.
Some manufactures have created cell wall free chlorella extracts (NDF, PCA)
which are very expensive, less effective - but easily absorbed.
This is a heat
extract from chlorella that concentrates certain peptides, proteins and other
ingredients. The research on CGF shows that children develop no tooth decay and
their dentition (maxillary-facial development) is near perfect. There are less
illnesses and children grow earlier to a larger size with higher I.Q and are
socially more skilled. There are case reports of patients with dramatic tumor
remissions after taking CGF in higher amounts. In our experience, CGF makes the
detox experience for the patient much easier, shorter and more effective.
Recommended dosage: 1
cap. CGF for each 20 tabl.chlorella
Garlic (allium
sativum) and wild garlic (allium ursinum)
Garlic has been shown to protect the white and red blood cells from oxidative damage, caused by metals in the blood stream - on their way out – and also has ist own valid detoxification functions. Garlic contains numerous sulphur components, including the most valuable sulph-hydryl groups which oxidize mercury, cadmium and lead and make these metals water soluble. This makes it easy for the organism to excrete these subastances. Garlic also contains alliin whis is enzymatically transformed into allicin, natures most potent antimicrobial agent. Metal toxic patients almost always suffer from secondary infections, which are often responsible for part of the symptoms. Garlic also contains the most important mineral which protects from mercury toxicity, bio active selenium. Most selemium products are poorly absorbable and do not reach those body compartments in need for it. Garlic selenium is the most beneficial natural bioavailable source. Garlic is also protectice for against heart disease and cancer.
The half life of allicin (after crushing garlic) is less then 14 days. Most commercial garlic products have no allicin releasing potential left. This distinguishes freeze dried garlic from all other products. Bear garlic tincture is excellent for use in detox, but less effective as antimicrobial agent.
Dosage: 1-3 capsules
freeze dried garlic after each meal. Start with 1 capsule after the main meal
per day, slowly increase to the higher dosage. Initially the patient may
experience die-off reactions (from killing pathogenic fungal or bacterial
organisms). Use 5-10 drops bear-garlic on food at least 3 times per day.
Fish oil:
The fatty acid
complexes EPA and DHA in fish oil make the red and white blood cells more
flexible thus improving the microcirculation of the brain, heart and other
tissues. All detoxification functions depend on optimal oxygen delivery and
blood flow. EPA and DHA protect the brain from viral infections and are needed
for the development of intelligence and eye-sight. The most vital cell organelle
for detoxification is the peroxisome. These small structures are also
responsible for the specific job each cell has: in the pineal gland the
meltonin is produced in the peroxisome, in the neurons dopamine and
norepinephrine, etc. It is here, where mercury and other toxic metal attach and
disable the cell from doing its work. Other researchers have focussed on the
mitochondria and other cellorganelles, which in our experience are damaged much
later. The cell is constantly trying to make new peroxisomes to replace the
damaged ones– for that task it needs an abundance of fatty acids, especially
EPA and DHA. Until recently it was believed, that the body can manufacture ist
own EPA/DHA from other Omega 3 fatty acids such as fish oil. Today we know,
that this process is slow and cannot keep up with the enormous demand for
EPA/DHA our systems have in todays toxic environment. Fish oil is now
considered an essential nutrient, even for vegetarians. Recent research also
revealed, that the transformation humans underwent when apes became intelligent
and turned into humans happened only in coastal regions, where the apes started
to consume large amounts of fish. Why not benefit from that knowledge and
consume more fish oil?
The fatty acids in
fish oil are very sensitive to exposure to electromagnetic fields, temperature,
light and various aspects of handling and processing. Trans fatty acids, long
chain fatty acids, renegade fats and other oxydation products and contaminants
are frequently found in most commercial products. Ideally, fish oil should be
kept in an uninterrupted cooling chain until it ends up in the patients fridge.
The fish-source should be mercury and contaminant free, which is becoming
harder and harder. Fish oil should tast slightly fishy but not too much. If
there is no fish taste, too much processing and manipulation has destroyed the
vitality of the oil. If it tastes too fishy, oxydation products are present. I
recommend to use the product recommended below (grade I), where meticulous care
has been taken to comply with all the necessary parameters. The clinical
results are outstanding.
Dosage: 1 capsule
Omega 3 taken 4 times/day during the active phase of treatment, 1 caps.
twice/day for maintainance
Best if taken
together with chlorella
The VegiPearls
contain half the amount of EPA/DHA. The vegetarian capsules eliminate even the
most remote possibility of containing prions and make the idea of taking fish
oil more easily acceptable for vegetarians. Recently a fatty acid receptor has
been discovred on the tongue, joining the other more known taste receptors. If
the capsules are chewed, the stomach and pancreas start to prepare the
digestive tract in exactly the right way to prepare for maximum absorption.
Children love chewing the VegiPearls.
To treat bipolar
depression, post partum depression and other forms of mental disease, 2000 mg
of EPA are needed/day (David Horrobin). For the modulation of malignancies, 120
mg of EPA 4 times/day are needed. The calculations can easily be done with the
information given on the label.
Balanced
electolyte solution (Selectrolyte)
The autonomic nervous system in most toxic patients is dysfunctional. Electric messages in the organism are not received, are misunderstood or misinterpreted. Toxins cannot be shuttled through the extracellular space. Increased intake of natural ocean salt (celtic sea salt) – and avoidance of regular table salt - has been found to be very effective in resolving some of these problems. Most effective is a solution pioneered by the American chemist Ketkovsky. He created the formula for the most effective electrolyte replacement, which was further improved by Morin Labs, and is now called „selectrolyte“. I recommend this to all my patients and have observed, that every aspect of the detoxification process seems to be enhanced. 5 % of the population is sodium or chloride sensitive – the blood pressure goes up (easily reversible). In these patients the detox process takes longer and is more difficult.
Dosage: 1 tsp in a
cup of good water 1-3 times/day During times of greater stress the dosage can
be temporarily increased to 1 tbsp 3 times/day
More agressive
approaches, such as i.v Glutathione, Vit.C, DMPS, CaEDTA and others have a
place in reasonably healthy people but often worsen the condition in patients
with advanced illness.
Most valuable is
the addition of psychotherapeutic interventions such as applied
psychoneurobiology (APN) and mental field therapy (MFT) to trigger the release
of toxins from their hiding places.
Chlorella, cilantro, garlic-products and fatty acids vary greatly in quality and nutrient content, also in content of contaminants. I no longer recommend BioReurella and other products that have not undergone or passed our quality control screening process.
October 2002
Dietrich Klinghardt,
MD, PhD
Bellevue, Washington,
USA
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