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Go forth & heal!
Dr. Yasko’s presentation
10:30 am
Strep
Underlying this is see chart
IOM Report of June 15, 2004 “ The Proven and suspected roles…especially in children.”
“Most cases of schizophrenia (Autism should be put here) are caused by INFECTIONS and other ENVIRONMENTAL EVENTS OCCURRING IN GENETICALLY SUSCEPTIBLE individuals.”
MTHFR & COMT & GAD & etc. set of factors play a role in genetic suseptability
Herpes infection could be a really old exposeure (in birth canal) & re- exposure like from a cat…this combo will cause the schizophrenia
Parasites impair immune response to Tatanus vaccine
p. 16 # 4 Antibodies cross-react and cause different organ impairment
Strip has a number of effects. On it’s own can increase glutamate & decrease glutathione
Low level of glutathione can actually fuel the strep rather than help child
p. 16 #5 Step because of structures it exacer bates leaky gut, and enables viral spread, w/o methylation yowza
H2O2 increase
Decrease tyrosine
Great chart
Breaks NAD so more need for NADH esp. with glutathione supplementation
Must have Vit K to regulate calcium
Hydrogen Pyroxide levels
Page 17 #1
Decreased tyrosine leads to decreased dopamine
Do they tan in the sun…if they don’t chart # 1 is a problem!!!!!!!!!!
#2
TNF alpha…one of the worst inflammatory mediators because it can creat more of itself so
#3 Connectivity mafp of TNF alpha…what a map…have to keep TNF alpha under control
#4
Strep has identifying proteins on it & the receptors for strep are the same as for Measles & herpes…so once you have the fishing poles out there they are generally a combo of strep, measles & herpes together
Boils whaile they are excreting metals
#6
Niacinimide can inhibit virus, and bacteria depletesthis so the bacterial infection reduces the ability of the body to keep the virus aty bay because of lack of this
#^ Glutathione (certain forms only) will reduce NADH Krebls cycle test will get stu8ck at:
Worth supplementing NADH despite expense if you are supplementing glutathione
Strep takes another hit on Dopamine & seratonin
#*
Nadh
Krebs cycleif pooling on last half of krebs cycle need DADH or different form of glutathione
18-1
2/3 of supply of NADH is lost by defeacts so need niacinimide & NADH
2
Tryptophan necessary for serotonin & melatonis
Too much IDO need a methyl group to appropriately inhibit IDO
Kynurenic JACID
B6 will make them more hyper of breaking down tryptophane but getting stuck at Quinolinic Acid, so first need to supplement ahead of it
Niacinamide will save tryuptophan to go to serotonin & melatonin
B3 antibiotic, kills virus, kills lyme
4
more complex pathway IDO, Tryptophan is saved if supplementing B3
5
low serotonin equals increase perseverative behavior
CO2 increase serotons (selzer water can help serotonin receptors (Boyond C & THE Right C are nutrients thatshake c into selzer water, helps transport nutrients past the blood brain barrier
19
total map out (increase ssensitivity to phenols
most have low IGF levels, should supplement after you have glutamate & calcium levels under control
2
3 Same is one of her favorite supplements because it helps with BH$ (helps with phenol sensitivity
4
Stress results in all the same fproblems (must avoid..errorlass learning)
Video on stress available.. body is stupid whan it comes to stress…it can’t differientiatee between the different kinds…old mechanism…chronis infections triggers this process all the time
5
chronic strep result in all the same bad stuff – avoikd glutamate, supplement the right glutathione with NADH & Nicin
6
Xylitol for use in BIOTNE at ritht adi, used for nasal infections helps wwith leaky gut as an added benefit
HEAVY METAL BURDEN
20-2
BOTH VACCINES FROM KIDS & SCHEDULE OF VACCINES AS ADULTS OF MOMS MAY BE ANOTHER PREDISPOSING FACTOR
3
list of bridges GSH on cells which leads to depletion of T cell activation
T cells & B cells
T are smart, B not so smart
You end up with improper & unregulated inflammatory immune response
4
EDTA may be an ADAptogen to help balance things that are out of balance & can balance mylenation
5
thimerisol is in there as an anti-microbial agent
that is why there is no thimerisol in the MMR because it is a live virus vaccine so you don’t want to kill it with the Thimerisol
Hormaones may be non-existant when really sick
6
BH4 is compromise because of pre-disposing factors (espec. Lead to further reduce seratonin & Dopamine
21
Heme synthesis is impaired by lead lower red blood cells (no iron for any of these kids because it will fuel the neurological system & STREP loves IRON…so instead get rid oof the lead & the red blood cells come up
Glutamate burdens this as well because the breakdown to a usable substreat is impaired by lead
2
3
great sentence
mercury & lead together are much worse in the precence of glutamate
4
lead leads to all types of synergistically bad problems which make wven low doses of thimeerisol ind up causing nerve damage
5
Nickel further de reases SAMe level which she loves ( nmethyl donor etc.
May compromise ability to repair that pathway
6
high metal decrease myelination …vicious cycle of raw nerves
22
1
myelination is the coating…transmission requirment
2 must methylate to coat these nerves
3
Neuregulins…constant triggering of this will cause demyelination
5
fishing poles…if don’t have enough fishing poles for the neuregulin to bind to will have thinly myelinated nerves
6
need neuregulin, but the fishing pole may have problems with mercurty
23
neuregulin trips cascad (Dr. Aquilar FGF feeds into the same pathway as the neureguln…possible benefit of Fgf to stimulate myelination, Iy problem when break between MEK & ERK
Kids sem to have good spatial lerarning & fear conditioning but the other direction
2
if nerves are not myelinated they will continue to grow & get all tangled
EDTA plays an important role in ths process along with neuroeglin
3
mature neurons require myelination & can’t transmit information properly
4
nerves get shorteer, more myelinated & more complex
5
without myelin nerves will continue to grow & not prune
6
chart
24
cholesterol
lipids are circular molegules with tails gioing inward, but if the tails are rigid thatn transport problem with protein & nerves
ratio of EFA is important
Lipid fluidityh is important
Reeling receptor is the LDL receptor
2
MD – tie in with lipids & neurological illness is well documented
3 – graph of
4
chronic viral infection
viruses have coats that have molecules that stick out to attach to things
5
when it is in the cell it buds out of host cells & when it comes out it has part of hast cells on t
it
6
251
retrovirus…measles & mumps…
rubella in precence of retroviruses can behave like one to get stuck intra-cellular in lack of methylation environment
2
think them like parasites, they don’t want to kill you they survive off of you
3
loaded with metals equals a permanent host
MT proteins are triggere & used by viruses
Low MT may not be a genetic defeact but infact the viruses gobbling it up before you can detect it./
4
virus can trigger host MT synthesis which traps more metals intra-cellaularly
4
IDO is increase in pregnancy to not reject the fetus, but if a person that is immune compromise with reduced IDO won’t recognize it as non-self when sneezed on
Chicken pox is a herpes virus
6
26-1
measles affects the gut wakefield
mumps may effect hormones
rubella may affedct the pancreas
all can insert into the DNA
3
4
affects sensitivity of pain & when combined with the CO”MT mutation ?
5
Rubella – leaky gut
6 big X thru this because it does not work
27
1
2nd highest source of vit k next to the blood
2
3
check into Bob Claeys doctor s work in Texzas
4
same stuff exacerbated
5
chart
6
genetics: gender, bllod type & HLA type
male, blood type (eat right for your blood type – strep & virus more dominant in some)
Type O & A is all she hs found in autism
O has pr9oblem with wheat and milk
28
2
history of asthma & relationship to retro virus
3
HLA type antigens on the surface of the cell (do you have triangles or circles over simplified) it is what they use to match donor organs
3
4
your HLA type will predict your response to the measles vaccine
6
as the virus buds thru the cell it will pick up the host marker.
Huge in rubella virus because it is grown un human tissue (girls) & so if it is the same it may not see it as foreign & result in chronic infection, foreigtn but not enough IDO will not recognize it, same with chronic viral infections…so genetic makeup makes a huge difference in how you respond to the vaccines
29
3
DPT vaccine toxoid for vaccine is tested on immunocompetent animals & it is fine 4
5
inactivated toxiod acts like the toxin but in normal immune response fine, compromised results in toxoid fresponse
6
Tetanus cut rope on boat, can’t communicate & creates a problem
30-2
Tetanus toxin blocvks release of GABA ---TENLEY !!!!!
Role of acetylcholine because this can impair its breakdown &
3
causes build up of acetylcholine & can cause opposing behaviors
4
goo much acetylcholine decrease muscarinic receptors all activity at nicotenomide
5
list of
6
permenant damage of tetanus toxin
31
cumulative list again
1
Nerological Research Institute News letter she highlights what she finds
Questions:
Mitochondrial issues engine to drive energy & yes she thinks it is a proglem
Cytochromes banging electorons in the membrane & final storage is CoQ 10 so if problems will have problems generating energy & supplements are designed to enhance this energy output
Secretin… noticed it did temporarily improve speech, GABA, why…there may be more than one pathway where secretin can help, tryptophan down to niacinimide. There may be synonymous feedback pathways so if you have sufficient secretin may not need the GABA to be made or utilized
Guy from Europe found no levels of deficiency in Vit D or K but she says when supplement it she sees great results
Health Foundation to reduce inflammation
Noticed high CoQ10 & could see opposite presentation iron hemoglobin
Back up of system would result in high levels of CoQ10 & iron
Loctoferrin will bring iron down
If high CoQ10 building up, may have to look farther down on the pathway & supplement something other than CoQ10
GAD enzyme – can yhou supplement it directly ? Bob
Glutamate to gaba some may have the genetic mutation of GAD (at DNA level)
So many mutations could look like autism
But generally have auto-antibodies to that enzyme which inactivates it, so something like colostrums etc. will slow this down & allow body to use the GAD it already has
Melanie Rhett’s syndrome defect ? cascade? Similar consequences without all defects
There are tests with a swab that will look at most of these defects quite well to determine path.
Whether or not bypassing the folic acid pathway will
Parasites & tetanus depressed resonse to tetanus toxoid
Nicotene helps with the acetylcholine receptors
England methylation, selenium, keeps virus asleep and inactivates the mercury
She believes in a little bit of a lot of things…she likes selenium very much.
Be wary of negative metal test, what about neg tests for strep etc.
She always looks at testsfrom two standpoints:
Do low levels mean diversion & too much
She looks at total picture & symptomology rather than test alone.
What about all of behaviors but neg test…she would suspect it is there.
FGF supplementation caused hyperactivity. It is a growth & methyl donor & increases dopamine, but iv have the COMT mutation than go a lot slower because it may be getting stuck at dopamine. May have to do 1/4 or 1/8 of dose.
M
Methylation – does it result in increase cancer risk in autism…crack in the sidewalk theory, water alwayts go down the crack, body uses same inflammatory metiators, so what she has observed is the body has a weak spot & it stays there, neurological stays neurological etc. , she has never seen anything to suggest this.
England – undermethylation (Bruce Aims) huge in cancer,
Apoptosis? From freeing up these genes.
Immune system tends to be on hyper drive & not getting sick, but once filled it comes back.
Reelin protein creates extended issue from
OCD – strep infection sharing toothepaste story with two kids.
Lyme disease is predisposing in type B blood kids. There are cat’s claw chronic bacterial (intracellular low NADH, tryptophan, niacin, glutathione, but getting glutamate & gaba under control will help a ton.
Virus has multiple ways to hold on to these metals (MT, inside cell, effect on methylation pathway)
Don’t have to get metals out of the child to